Case study – Exosomes

SPARTA® Analysis of Exosomes/Extracellular Vesicles as Cancer Biomarkers

Exosomes or Extracellular Vesicles (EVs) are an actively studied class of cell derived nanoparticles with a wide range of promising applications, from biomarkers for disease diagnosis to sophisticated drug delivery vesicles. SPARTA®’s powerful single particle compositional analysis can be used to generate detailed fingerprints of individual exosomes to reveal their lipid, protein and nucleic acid contents. This can be used to screen exosomes of different origins to, for instance, distinguish between cancer and non-cancer derived exosomes.

SPARTA® analysed over 14,000 single exosomes and could distinguish between exosomes from cancer and non-cancer breast epithelial cells. Differentiation between cancer and non-cancer cell derived extracellular vesicles was achieved with over 95% sensitivity and specificity.

Penders et al. ‘Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers.’ ACS Nano. 2021
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