SPARTA® is powered by our proprietary rapid automated trapping algorithm to perform single nanoparticle measurements providing Raman spectroscopy data at the touch of a button with virtually no sample preparation.
We have published the core concepts behind SPARTA® in the high-impact journal Nature Communications open-access available:
A 50:50 mixture of deuterated and non-deuterated liposomes was analysed by SPARTA®. Hundreds of particles were trapped, and the spectra analysed for the characteristic deuterium peak. A histogram with clear bimodal distribution was produced, showing the mixture was clearly resolved.
Polystyrene nanoparticles of 200 nm, 100 nm and 50 nm in diameter were analysed by SPARTA® in the presence of a solution marker. The individual size distributions of the particle populations were clearly resolved, whilst simultaneously obtaining their compositional information.
A model system of a copper catalysed azide-alkyne cycloaddition (click) reaction was analysed by SPARTA®. The reaction could be conducted and monitored either while trapping single particles sequentially, or by holding a single particle continually in the trap. The series of changing Raman spectra showed the progression of the reaction in real-time.
SPARTA® meets the pharmaceutical and biotechnology industry's need for the individual analysis of nanoformulations by enabling accurate chemical analysis of nanoparticles in a compact bench-top product using next-generation innovation.